Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, etc. |
| Sample | osteosarcoma cell lines (MG-63, U2OS, SAOS-2), hFOB cell line. osteosarcoma tissues, normal bone tissues. |
| Expression Pattern | down-regulation |
| Function Description | In conclusion, our data support TUG1 as a potential prognostic predictor and gene therapy target with its high expression in tumor tissues and its association with carcinogenesis and progression in osteosarcoma.TUG1, which is induced by p53, can also bind to PRC2 and miRNAs and then play pivotal suppressor role in cancer cell growth. It was also reported that TUG1 promotes cell growth and apoptosis by epigenetically silencing of KLF2; Kaplan-Meier curve showed a decreased overall survival time of osteosarcoma patients with high TUG1 expression. |
| Pubmed ID | 29970697 |
| Year | 2018 |
| Title | Role of taurine upregulated gene 1 as a predictor of poor outcome in osteosarcoma. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |