Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot etc. |
| Sample | bladder cancer tissues, cell lines (SW780, HT1376, BIU87 and T24) |
| Expression Pattern | up-regulated |
| Function Description | The levels of TUG1 and HMGB1 were remarkably increased in bladder cancer tissues and cell lines. TUG1 knockdown inhibited cell proliferation, promoted cell apoptosis and decreased colony survival in SW780 and BIU87 cells under radiation. |
| Pubmed ID | 28376901 |
| Year | 2017 |
| Title | Down-regulation of LncRNA TUG1 enhances radiosensitivity in bladder cancer via suppressing HMGB1 expression |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |