Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | osteosarcoma tissues, cell lines (MG-63, U2OS and MNNG/HOS) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 was elevated and correlated with a poor prognosis in osteosarcoma patients. Decreased TUG1 could remarkably inhibit osteosarcoma cell migration and invasion. Furthermore, the results of a real-time quantitative PCR showed that TUG1 and miR-335-5p could affect each other's expression. respectively. Finally, we affirmed that TUG1 affected ROCK1 expression and ROCK1-mediated migration/invasion by working as a competitive endogenous RNA (ceRNA) via miR-335-5p. |
| Pubmed ID | 28205334 |
| Year | 2017 |
| Title | Long non-coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR-335-5p in osteosarcoma cells. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |