Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RNA-seq, qPCR, RIP, Cell proliferation assay etc. |
| Sample | NSCLC tissues, cell lines (H520, H1299, and REH) |
| Expression Pattern | down-regulated |
| Function Description | TUG1 was significantly downregulated, and the TUG1 downregulation correlated with sex, smoking status, and tumor differentiation grade. Knockdown of TUG1 significantly promoted the proliferation of NSCLC cells. Using TUG1 4C sequencing and bioinformatic analysis, we found CELF1 to be a potential target of TUG1 RNA in in-trans regulation. Moreover, subsequent experiments showed that TUG1 RNA could bind to PRC2 in the promotor region of CELF1 and negatively regulate CELF1 expressions in H520 cells. |
| Pubmed ID | 27485439 |
| Year | 2016 |
| Title | Long noncoding RNA TUG1 is downregulated in non-small cell lung cancer and can regulate CELF1 on binding to PRC2. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |