Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, Flow cytometry assay, MTT assay etc. |
| Sample | CRC tissues, cell lines (HT-29-P/HT-29-R cell and HCT-8) |
| Expression Pattern | up-regulated |
| Function Description | Here, we observed lncRNA TUG1 was associated to the MTX resistant in colorectal cancer cells.Firstly, quantitative analysis indicated that TUG1 was significantly increased in tumors which were resistant to MTX treatment.TUG1 knockdown re-sensitized the MTX resistance in colorectal cancer cells, which were MTX-resistant colorectal cell line. |
| Pubmed ID | 28302487 |
| Year | 2017 |
| Title | TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |