Basic Information
| LncRNA/CircRNA Name | CASC15 |
| Synonyms | CASC15, LINC00340, lnc-SOX4-1 |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase assay, RIP etc. |
| Sample | B-ALL and AML patients tissues, cell lines (RS4, 11, MV4, 11, REH, 697, Nalm-6, and 70Z/3 and the HEK 294 T cell line) |
| Expression Pattern | up-regulated |
| Function Description | CASC15 is a conserved lncRNA that was upregulated in pediatric B-acute lymphoblastic leukemia (B-ALL) with t (12; 21) as well as pediatric acute myeloid leukemia (AML) with t (8; 21), both of which are associated with relatively better prognosis. |
| Pubmed ID | 28724437 |
| Year | 2017 |
| Title | The lncRNA CASC15 regulates SOX4 expression in RUNX2-rearranged acute leukemia. |
External Links
| Links for CASC15 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |