Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, ChIP, Flow cytometry assay etc. |
| Sample | GBM tissues, cell lines (1228-GSC and 222-GSC) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 expression in GBM tissues (n=24) was significantly higher than in normal brain tissues. Treatment with TUG1-DDS markedly reduced tumour growth compared with control-DDS (CTRL-DDS) together with the downregulation of TUG1 expression |
| Pubmed ID | 27922002 |
| Year | 2016 |
| Title | Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |