Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, MTT assay etc. |
| Sample | OSCC tissues, cell lines (SCC-25, CAL-27, Tca8113, and TSCCA) |
| Expression Pattern | up-regulated |
| Function Description | UG1 was up-regulated in both OSCC tissues and cell lines. The high expression level of TUG1 was significantly correlated with TNM stage, lymph node metastasis and tumor grade in OSCC patients. Knock-down of TUG1 by siRNA transfection suppressed cell growth, cell proliferation, and cell invasion in OSCC cell lines. In addition, knock-down of TUG1 in Tca8113 and TSCCA cells significantly suppressed the mRNA and protein expression levels of B-catenin, cyclin D1, and c-myc. Wnt/B-catenin pathway activator (LiCl) reversed the TUG1 knock-down effect on cell proliferation, cell invasion and cell apoptosis in Tca8113 and TSCCA cells. |
| Pubmed ID | 28119088 |
| Year | 2017 |
| Title | LncRNA, TUG1 regulates the oral squamous cell carcinoma progression possibly via interacting with Wnt/B-catenin signaling. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |