Basic Information
| LncRNA/CircRNA Name | CASC15 |
| Synonyms | CASC15, LINC00340, lnc-SOX4-1 |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | B-acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase assay, RIP etc. |
| Sample | B-ALL and AML patients tissues, cell lines (RS4, 11, MV4, 11, REH, 697, Nalm-6, and 70Z/3 and the HEK 293 T cell line) |
| Expression Pattern | up-regulated |
| Function Description | CASC15 is a conserved lncRNA that was upregulated in pediatric B-acute lymphoblastic leukemia (B-ALL) with t (12; 21) as well as pediatric acute myeloid leukemia (AML) with t (8; 21), both of which are associated with relatively better prognosis. CASC15 regulated cellular survival, proliferation, and the expression of its chromosomally adjacent gene, SOX4. Differentially regulated genes following CASC15 knockdown were enriched for predicted transcriptional targets of the Yin and Yang-1 (YY1) transcription factor. Interestingly, we found that CASC15 enhances YY1-mediated regulation of the SOX4 promoter. CASC15 in RUNX1-translocated leukemia, and point towards a mechanistic basis for its action. CASC15 expression was not statistically associated with survival by Kaplan-Meier analysis or in a multivariate regression model |
| Pubmed ID | 28724437 |
| Year | 2017 |
| Title | The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia. |
External Links
| Links for CASC15 | GenBank HGNC NONCODE |
| Links for B-acute lymphoblastic leukemia | OMIM COSMIC |