Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | pancreatic tumor tissues, cell lines (PANC-1, AsPC-1, HEK 293T) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 was overexpressed in PC tissues and cell lines, and high expression of TUG1 predicted poor prognosis. at least partially, by functioning as an endogenous ??ponge??and competing for miR-382 binding to the miRNA target EZH2. |
| Pubmed ID | 28813705 |
| Year | 2017 |
| Title | The Lncrna-TUG1/EZH2 Axis Promotes Pancreatic Cancer Cell Proliferation, Migration and EMT Phenotype Formation Through Sponging Mir-382 |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |