Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, Flow cytometry assay, Cell migration and invasion assay etc. |
| Sample | SCLC tissues, cell line (NCI-H69, NCI-H446, NCI-H69AR) |
| Expression Pattern | up-regulated |
| Function Description | We found that TUG1 was overexpressed in SCLC tissues. Moreover, downregulation of TUG1 expression could impair cell proliferation and increased cell sensitivity to anticancer drugs both in vitro and in vivo. We also discovered that TUG1 knockdown significantly promoted cell apoptosis and cell cycle arrest, and inhibited cell migration and invasion in vitro. We further demonstrated that TUG1 can regulate the expression of LIMK2b via binding with enhancer of zeste homolog 2 (EZH2), and then promoted cell growth and chemoresistance of SCLC. |
| Pubmed ID | 28069000 |
| Year | 2017 |
| Title | Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |