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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	epithelial ovarian cancer
ICD-0-3	C56.9
Methods	qPCR, Western blot etc.
Sample	epithelial ovarian cancer tissues, cell line (SKOV3)
Expression Pattern	up-regulated
Function Description	LncRNA TUG1 expression was higher in tumor tissue compared to paired adjacent tissue, and it was positively correlated with pathological grade, tumor size and FIGO stage . Kaplan-Meier curve showed that lncRNA TUG1 high expression was associated with worse OS . Multivariate Cox analysis indicated that lncRNA TUG1 high expression (vs. low expression) was independently predictive factor for shorter OS. In vitro, cells proliferation was promoted after treatment with lncRNA TUG1 mimic and was suppressed after treatment with lncRNA TUG1 inhibitor. In addition, cells apoptosis rate was decreased in lncRNA TUG1 mimic group compared to NC1 mimic, and increased in lncRNA TUG1 inhibitor group compared to NC2 inhibitor.In conclusion, lncRNA TUG1 is positively correlated with advanced disease and poor prognosis, and it promotes cells proliferation and inhibits cells apoptosis in EOC cells.
Pubmed ID	29742691
Year	2018
Title	Long non-coding RNA taurine-upregulated gene 1 predicts unfavorable prognosis, promotes cells proliferation, and inhibits cells apoptosis in epithelial ovarian cancer.

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