Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatoblastoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | hepatoblastoma tissues, cell lines (HepG2, HuH-6, and SMMC-7221) |
| Expression Pattern | up-regulated |
| Function Description | We show that TUG1 is significantly upregulated in human hepatoblastoma specimens and metastatic hepatoblastoma cell lines. TUG1 knockdown inhibits tumor growth and angiogenesis in vivo, and decreases hepatoblastoma cell viability, proliferation, migration, and invasion in vitro. TUG1, miR-34a-5p, and VEGFA constitutes to a regulatory network, and participates in regulating hepatoblastoma cell function, tumor progression, and tumor angiogenesis. |
| Pubmed ID | 27362796 |
| Year | 2016 |
| Title | Targeting long non-coding RNA-TUG1 inhibits tumor growth and angiogenesis in hepatoblastoma. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for hepatoblastoma | OMIM COSMIC |