Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot etc. |
| Sample | thyroid cancer tissues, cell lines (ATC, SW1736, KAT18, FTC, FTC133, HGC-27) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 contributes to the progression of thyroid cancer cells through regulating miR-145/ZEB1 signal pathway.LncRNA TUG1 was found to be up-regulated in thyroid cancer tissues and thyroid cancer cells compared with that in the human normal breast epithelial cell HGC-27.Increased lncRNA TUG1 expression was found to significantly promote tumor cell proliferation,and facilitate cell invasion,while down-regulated TUG1 could obviously inhibit cell proliferation,migration/invasion and reverse EMT to MET.These results indicated that TUG1 may contribute to the progression of thyroid cancer cells by function as a ceRNA competitive sponging miR-145,and that lncRNA TUG1 is associated with tumor progression in thyroid cancer cells. |
| Pubmed ID | 28645161 |
| Year | 2017 |
| Title | LncRNA TUG1 influences papillary thyroid cancer cell proliferation, migration and EMT formation through targeting miR-145. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |