Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | GBC tissues, cell lines (EH-GB1, GBC-SD, NOZ, SGC-996) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 expression was significantly overexpressed in GBC tissues.Functionally, this study demonstrated that knockdown of TUG1 significantly inhibited GBC cell proliferation, metastasis.Mechanically, we found that TUG1 is upregulated by TGF-B1, and knockdown of TUG1 inhibited GBC cell EMT.Furthermore, we identified that miR-300, which has been reported as a suppressor in other types of cancer, is negatively regulated by TUG1 |
| Pubmed ID | 28178615 |
| Year | 2017 |
| Title | Long non-coding RNA TUG1 promotes cell proliferation and metastasis by negatively regulating miR-300 in gallbladder carcinoma. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |