Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | NA |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, RIP |
| Sample | The CC cell lines (HeLa, C4-1, SiHa and CaSki), the immortalized squamous cells , The CC tissues and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | TUG1 was upregulated in CC, especially in those with worse TNM staging and larger tumor size. The overexpression of TUG1 enhanced proliferative and migratory abilities of Hela and SiHa cells. TUG1 was mainly distributed in the cytoplasm. PUM2 interacted with TUG1 and its level was positively regulated by TUG1. The silence of PUM2 reversed the promotive effect of TUG1 on the viability of the CC cells. |
| Pubmed ID | 31646551 |
| Year | 2019 |
| Title | LncRNA TUG1 aggravates the progression of cervical cancer by binding PUM2 |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |