Basic Information
| LncRNA/CircRNA Name | CASC15 |
| Synonyms | CASC15, LINC00340, lnc-SOX4-1 |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | hepatocellular carcinoma tissues, cell lines (SMMC7721, Hep-G2,Huh-7, HCCLM3, Hep3B, QSG-7701) |
| Expression Pattern | up-regulated |
| Function Description | CASC15 was overexpressed in HCC tissues compared with corresponding adjacent normal tissues, and the CASC15 expression level was significantly correlated with metastasis,tumor size,and TNM stage.high CASC15 expression was associated with poor prognosis in HCC patients.CASC15 significantly impaired HCC cell proliferation, migration, and invasion.CASC15 knockdown also induced cell apoptosis in vitro and impaired tumor growth in vivo. |
| Pubmed ID | 29075788 |
| Year | 2017 |
| Title | Long non-coding RNA CASC15 is upregulated in hepatocellular carcinoma and facilitates hepatocarcinogenesis. |
External Links
| Links for CASC15 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |