Detail

Basic Information

LncRNA/CircRNA Name	CASC15
Synonyms	NA
Region	GRCh38_6:21664772-22368328
Ensemble	ENSG00000272168
Refseq	NR_015410

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	prostate cancer
ICD-0-3	C61.9
Methods	qPCR, Luciferase reporter assay, in vitro knockdown
Sample	The PC cell lines (LNCaP, DU145 and 22Rv1) and normal human prostate epithelial cell line (P69), PC tissue, adjacent tissues
Expression Pattern	up-regulated
Function Description	CASC15 expression level was significantly higher in PC tissues and cell lines. Results of wound healing assay and transwell assay revealed that cell migrated ability and invaded ability were suppressed via silence of CASC15 in PC cells. Furthermore, the expression of miR-200a-3p was upregulated via silence of CASC15 in PC cells. Luciferase assay showed that miR-200a-3p was a direct target of CASC15 in PC. In addition, miR-200a-3p expression was negatively correlated with CASC15 expression in PC tissues. Rescue experiments also revealed that the inhibition of PC migration and invasion by silence of CASC15 could be reversed through knockdown of miR-200a-3p.
Pubmed ID	31646560
Year	2019
Title	LncRNA CASC15 promotes migration and invasion in prostate cancer via targeting miR-200a-3p

External Links

Links for CASC15	GenBank HGNC NONCODE
Links for prostate cancer	OMIM COSMIC