Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, other |
| Sample | CRC tissues and cell lines (SW620 and LoVo) |
| Expression Pattern | up-regulated |
| Function Description | The results demonstrated that the expression of TUG1 was positively associated with the pathological grade and clinical stage of CRC patients. Knockdown of TUG1 inhibited the proliferation of CRC cells and attenuated the activity of Wnt/?-catenin pathway in CRC cells. In addition, TUG1 knockdown inhibited the tumorigenicity in the in vivo CRC xenograft model, as well as the nuclear localization of ?-catenin and downstream gene transcription. Taken together, the data of the present study highlighted the pivotal role of the TUG1-Wnt/?-catenin signaling pathway in CRC, which could be targeted to improve the therapeutic efficacy of CRC. |
| Pubmed ID | 30250601 |
| Year | 2018 |
| Title | Long Non-Coding RNA TUG1 Promotes the Proliferation of Colorectal Cancer Cells Through Regulating Wnt/?-catenin Pathway |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |