Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | NA |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Dual luciferase activity assay |
| Sample | renal cell carcinoma tissues, cell lines(Caki-1, 769-P, HK-2, HEK293) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 was overexpressed in RCC and correlated with YAP mRNA levels in tumor tissues. we found that TUG1 could bind to miR-9. we observed that inhibition of cell proliferation and cell migration induced by TUG1 silencing could be reversed by overexpression of YAP in RCC cell lines. |
| Pubmed ID | 30132963 |
| Year | 2018 |
| Title | Long noncoding RNA TUG1 promotes cell proliferation and migration of renal cell carcinoma via regulation of YAP. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |