Detail

Basic Information

LncRNA/CircRNA Name	CASC15
Synonyms	NA
Region	GRCh38_6:21664772-22368328
Ensemble	ENSG00000272168
Refseq	NR_015410

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	non small cell lung cancer
ICD-0-3	C34
Methods	Microarray, qPCR, Western blot, in vitro knockdown
Sample	NSCLC cell lines (H1703, A549, SPCA1, NCI-H460 and NCI-1650) and normal bronchial epithelial cell line (HBE and NLECs), NSCLC tumor and matched normal lung tissues, NSCLC tumor and matched normal lung tissues
Expression Pattern	up-regulated
Function Description	We found that CASC15 was upregulated in NSCLC tissues and cell lines. High expression levels of CASC15 were correlated with malignancies and poor survival rate in NSCLC patients. Multivariate analysis revealed that CASC15 was an independent risk factor of prognosis. In addition, we demonstrated that CASC15 knockdown inhibited NSCLC cell proliferation, migration and invasion in vitro. Xenograft model showed CASC15 knockdown significantly suppressed NSCLC tumor growth. Mechanistically, we revealed that CASC15 regulated EMT-related molecules and promoted the NSCLC progression and metastasis.
Pubmed ID	31396336
Year	2019
Title	Long noncoding RNA CASC15 predicts unfavorable prognosis and exerts oncogenic functions in non small cell lung cancer

External Links

Links for CASC15	GenBank HGNC NONCODE
Links for non small cell lung cancer	OMIM COSMIC