Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | taurine-upregulated gene 1 |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Dual Luciferase Reporter Gene Assay, Western blot |
| Sample | Bone marrow tissue samples,AML cell lines (HL-60 and Kasumi-1) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of TUG1 markedly reduced viability and metastasis of AML cells, while its overexpression had the opposite effect.TUG1 could modulate malignant phenotypes of AML cells via miR-370-3p/MAPK1/ERK signaling. |
| Pubmed ID | 31819520 |
| Year | 2019 |
| Title | Long Non-Coding RNA TUG1 Modulates Proliferation, Migration, And Invasion Of Acute Myeloid Leukemia Cells Via Regulating miR-370-3p/MAPK1/ERK |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |