Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | taurine upregulated gene 1 |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, Dual luciferase reporter assay, Western blot assay |
| Sample | HCC tissues,HCC cell lines (HCC-2, Hep3B, Huh7 and CLC1) and normal cell line (THLE-2) |
| Expression Pattern | up-regulated |
| Function Description | there was a marked rise in TUG1 expression in HCC tissues and cells, and knockdown of TUG1 repressed the growth and metastasis and promoted apoptosis of HCC cells. In particular, TUG1 could act as a ceRNA, effectively becoming a sink for miR-216b-5p to fortify the expression of DLX2. Additionally, repression of TUG1 impared the progression of HCC cells by inhibiting DLX2 expression via sponging miR-216b-5p in vitro. More importantly, TUG1 knockdown inhibited HCC tumor growth in vivo through upregulating miR-216b-5p via inactivation of the DLX2. |
| Pubmed ID | 31920462 |
| Year | 2020 |
| Title | Long Non-Coding RNA TUG1 Promotes Cell Progression in Hepatocellular Carcinoma via Regulating miR-216b-5p/DLX2 Axis |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |