Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | turine up-regulated gene 1 |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, Luciferase activity assay, Western blotting |
| Sample | OC tissues,ovarian epithelial cell line IOSE-80 and 4 OC cell lines A2780, SKOV3, ES-2, and C30 |
| Expression Pattern | up-regulated |
| Function Description | the expression of TUG1 and MDM2 were significantly increased, but the expression of miR-29b-3p was remarkably decreased in OC tissues and cell lines. Knockdown of TUG1 strongly inhibited the ability of cell proliferation, colony formation, migration, and invasion in vitro. |
| Pubmed ID | 31930662 |
| Year | 2019 |
| Title | Long Noncoding RNA TUG1 Facilitates Cell Ovarian Cancer Progression Through Targeting MiR-29b-3p/MDM2 Axis |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |