Basic Information
| LncRNA/CircRNA Name | CASC15 |
| Synonyms | NA |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | NSCLC tissues and adjacent tissues ,NSCLC cell lines (SPCA1, H1299, PC-9, and H358) ,normal human bronchial epithelial cell line (16HBE) |
| Expression Pattern | up-regulated |
| Function Description | CASC15 expression was remarkably upregulated in NSCLC samples compared with that in adjacent samples. Cell proliferation, invasion, and migration in NSCLC were inhibited via knockdown of CASC15 in vitro. Moreover, miR-130b-3p was upregulated via knockdown of CASC15 in vitro. In addition, miR-130b-3p was a direct target of CASC15 in NSCLC. Tumor formation and metastasis were inhibited after CASC15 was knockdown in vivo. |
| Pubmed ID | 31599419 |
| Year | 2019 |
| Title | Long Noncoding RNA CASC15 Is Upregulated in Non-Small Cell Lung Cancer and Facilitates Cell Proliferation and Metastasis via Targeting miR-130b-3p |
External Links
| Links for CASC15 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |