Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | NA |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | hepatocellular carcinoma cell lines (SMMC 7721, HepG2 and BEL-7402) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA TUG1 expression was increased in SMMC 7721 cells, HepG2 cells and BEL-7402 cells compared to L-02 cells. After transfection of lncRNA TUG1 mimic and inhibitor plasmids, cells proliferation, migration and invasion were observed to be increased in lncRNA TUG1 mimic group compared to blank mimic group (NC1), while were decreased in lncRNA TUG1 inhibitor group compared with blank inhibitor group (NC2). As to cells apoptosis, AV/PI assay disclosed that lncRNA TUG1 mimic suppressed cells apoptosis rate than NC1 while lncRNA TUG1 inhibitor promoted cells apoptosis rate than NC2, apoptosis markers (C-Caspase3 and Bcl) protein expression also supported the regulation of lncRNA TUG1 on cells apoptosis. In addition, lncRNA TUG1 positively regulated the protein and mRNA expressions of AURKA, but not SERPINE1 or BRAF. |
| Pubmed ID | 31949695 |
| Year | 2018 |
| Title | Long Non-Coding RNA Taurine-Upregulated Gene 1 Promotes Cells Proliferation, Migration and Invasion While Represses Apoptosis, and Upregulates AURKA Expression in Hepatocellular Carcinoma |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |