Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | NA |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi |
| Sample | prostate cancer tissues, cell lines (DU145, PC-3, LNCaP, and 22Rv1) |
| Expression Pattern | down-regulated |
| Function Description | Expression of TUG1 in PCa tissues is significantly higher than that of in normal paired tissues. TUG1 was highly expressed in diverse PCa cell lines. There was a significant decrease in proliferation both in DU145 and PC3 cells after knockdown of TUG1 determined by CCK8. Transwell assays showed the number of DU145 and PC3 cells in lower section were significantly reduced in the TUG1 knockdown groups compared with the control groups, which indicated that up-regulation of TUG1 promote cell invasion and metastasis. The results showed that DU145 and PC3 cells transfected with TUG1 siRNA had higher apoptotic rate in comparison with control cells. TUG1 promoted PCa cell invasion via regulating EMT. |
| Pubmed ID | 29967294 |
| Year | 2018 |
| Title | TUG1 Promotes Prostate Cancer Progression by Acting as a ceRNA of miR-26a |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |