Basic Information
| LncRNA/CircRNA Name | TUC338 |
| Synonyms | NA |
| Region | GRCh38_12:53464468-53465057 |
| Ensemble | ENSG00000282977 |
| Refseq | NR_109828 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, RNAi, Western blot, Northern blot etc. |
| Sample | cell lines (HepG2, PLC/PRF-5, Huh-7, SNU-182, SNU-449, and SK-Hep-1) |
| Expression Pattern | up-regulated |
| Function Description | Among these ucRNAs, the greatest change was noted for ultraconserved element 338 (uc.338), which was dramatically increased in human HCC compared with noncancerous adjacent tissues. Functional gene annotation analysis indicated predominant effects on genes involved in cell growth. These effects were experimentally demonstrated in both human and murine cells. siRNA to TUC338 decreased both anchorage-dependent and anchorage-independent growth of HCC cells. |
| Pubmed ID | 21187392 |
| Year | 2011 |
| Title | Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. |
External Links
| Links for TUC338 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |