Basic Information
| LncRNA/CircRNA Name | CASC15 |
| Synonyms | cancer susceptibility candidate 15 |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-qPCR, Dual Luciferase Reporter Assay, Western blot analysis |
| Sample | ovarian cancer tissues,ovarian cancer cell lines (OVCAR3, SKOV3, A2780, HO-8910, Caov3, and CP70) and human ovarian immortalized nontumorigenic ovarian surface epithelial cells (IOSE) |
| Expression Pattern | down-regulated |
| Function Description | the expression of CASC15 was lower in ovarian cancer tissues and cells by qRT-PCR. In addition, low expression of CASC15 was closely correlated with advanced TNM stage, moderate/poor differentiation, and larger size. Moreover, Kaplan-Meier survival analysis showed that patients with low CASC15 expression level had poorer overall survival and progression-free survival than those with high CASC15 expression.Overexpression of CASC15 prohibited the malignancy of ovarian cancer cells, including proliferation, colony formation, cell cycle, migration, and invasion, and promoted cell apoptosis. |
| Pubmed ID | 31695430 |
| Year | 2019 |
| Title | LncRNA CASC15 Functions As An Unfavorable Predictor Of Ovarian Cancer Prognosis And Inhibits Tumor Progression Through Regulation Of miR-221/ARID1A Axis |
External Links
| Links for CASC15 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |