Basic Information
| LncRNA/CircRNA Name | CASC15 |
| Synonyms | NA |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | RT-qPCR, Luciferase Reporter Gene Assay |
| Sample | tumor tissues,NPC cancer cell lines (CNE2, CNE1, 5-8F and 6-18B) and immortalized normal nasopharyngeal epithelial cell line (NP69) |
| Expression Pattern | up-regulated |
| Function Description | CASC15 expression in NPC tissues was markedly higher than that of adjacent non-tumor tissues. The proliferation, migration and invasion of NPC cells were significantly inhibited after knockdown of CASC15 in vitro.tumor formation and metastasis of NPC were significantly inhibited via knockdown of CASC15 in nude mice.CASC15 enhances NPC cell proliferation and metastasis via sponging miR-101-3p in vitro and in vivo. |
| Pubmed ID | 31696476 |
| Year | 2019 |
| Title | Long Non-Coding RNA CASC15 Promotes Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Downregulating miR-101-3p |
External Links
| Links for CASC15 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |