Basic Information
| LncRNA/CircRNA Name | TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 |
| Ensemble | ENSG00000237298 |
| Refseq | NR_038272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | The normal human lung epithelial cell line BEAS-2B and five human LAD cell lines (H157, HCC827, H1975, H1299 and A549) |
| Expression Pattern | down-regulated |
| Function Description | We found a remarkable increase of TTN-AS1 expression in LAD cell lines in comparison with BEAS-2B cells. Functionally, silencing TTN-AS1 resulted in inhibited cell proliferation and migration in LAD cells. Mechanically, TTN-AS1 knockdown enhanced the level of PTEN protein while reduced p-AKT level. Meanwhile, PTEN inhibition observably recovered the repressive effect of TTN-AS1 silence on the biological behaviors of A549 cells. What's more, we demonstrated that TTN-AS1 modulated PTEN expression not at mRNA level but protein level. Intriguingly, TTN-AS1 was uncovered to reduce PTEN stability via inhibiting the interactivity of PTEN with MAGI2. |
| Pubmed ID | 31027732 |
| Year | 2019 |
| Title | Long non-coding RNA TTN-AS1 promotes the progression of lung adenocarcinoma by regulating PTEN/PI3K/AKT signaling pathway |
External Links
| Links for TTN-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |