Basic Information
| LncRNA/CircRNA Name | TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 |
| Ensemble | ENSG00000237298 |
| Refseq | NR_038272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | osteosarcoma tissues and adjacent tissues ,human osteoblast hFOB 1.19 and osteosarcoma cell lines(Saos-2 and U-2OS) |
| Expression Pattern | up-regulated |
| Function Description | The lncRNA TTN-AS1 was highly expressed in osteosarcoma and was associated with poor prognosis. The lncRNA TTN-AS1 promoted cell viability and inhibited apoptosis. MiR-134-5p targeted MBTD1, which was regulated by lncRNA TTN-AS1. MBTD1 was highly expressed in osteosarcoma and was associated with poor prognosis. MBTD1 promoted cell viability and inhibited apoptosis, and knockdown of MBTD1 reversed the cancer-promoting effects of lncRNA TTN-AS1. Downregulation of lncRNA TTN-AS1 reduced drug resistance. |
| Pubmed ID | 31600142 |
| Year | 2019 |
| Title | LncRNA TTN-AS1 Regulates Osteosarcoma Cell Apoptosis and Drug Resistance via the miR-134-5p/MBTD1 Axis |
External Links
| Links for TTN-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |