Basic Information
| LncRNA/CircRNA Name | TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 |
| Ensemble | ENSG00000237298 |
| Refseq | NR_038272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | CRC tissues and corresponding adjacent normal tissues ,CRC cell lines (NCM460, HT-29, SW620, SW1990, SW480 and Lovo) |
| Expression Pattern | up-regulated |
| Function Description | TTN-AS1 upregulation was observed both in CRC tissues and cell lines. Knockdown of TTN-AS1 inhibited CRC cell proliferation and invasion, while enhanced cell apoptosis. Identified miR-376a-3p as a target of TTN-AS1. Transfection of miR-376a-3p inhibitor mitigated the alterations induced by TTN-AS1 knockdown. Moreover, TTN-AS1 positively regulated KLF15 via sponging miR-376a-3p. |
| Pubmed ID | 31610194 |
| Year | 2019 |
| Title | LncRNA TTN-AS1 Sponges miR-376a-3p to Promote Colorectal Cancer Progression via Upregulating KLF15 |
External Links
| Links for TTN-AS1 | GenBank HGNC NONCODE |
| Links for colorectal adenocarcinoma | OMIM COSMIC |