Basic Information
| LncRNA/CircRNA Name | TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 |
| Ensemble | ENSG00000237298 |
| Refseq | NR_038272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | lung adenocarcinoma tissues and matched noncancer tissues,Human bronchiolar epithelial cell line (BEAS-2B),human lung adenocarcinoma cell lines (H1975, A549, PC9,and H2073) |
| Expression Pattern | up-regulated |
| Function Description | TTN-AS1 was upregulated in tissues and cells of lung adenocarcinoma and associated with poor overall survival.TTN-AS1 promoted cell proliferation, migration, invasion, and epithelial-mesenchymal transition in lung cancer.TTN-AS1 directly bound with miR-4677-3p and negatively regulated miR-4677-3p. MiR-4677-3p rescued the inhibitive impacts of TTN-AS1 knockdown on lung adenocarcinoma.TTN-AS1 drove the invasion and migration of lung adenocarcinoma cells by targeting the miR-4677-3p/ZEB1 axis. |
| Pubmed ID | 31173403 |
| Year | 2019 |
| Title | LncRNA TTN-AS1 Drives Invasion and Migration of Lung Adenocarcinoma Cells via Modulation of miR-4677-3p/ZEB1 Axis |
External Links
| Links for TTN-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |