Basic Information
| LncRNA/CircRNA Name | TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 |
| Ensemble | ENSG00000237298 |
| Refseq | NR_038272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RT-qPCR, Dual Luciferase Reporter Gene Assay |
| Sample | Tissue Specimens,prostate cancer cell lines (22Rv1, DU145, and LNCaP) and normal human prostate epithelial cell line (P69) |
| Expression Pattern | up-regulated |
| Function Description | TTN-AS1 expression was remarkably higher in prostate cancer samples compared with that of corresponding ones. Moreover, proliferation and migration of prostate cancer cells were inhibited after TTN-AS1 was silenced. MiR-1271 was upregulated after the silence of TTN-AS1. Further mechanism assays showed that miR-1271 was a direct target of TTN-AS1 in prostate cancer. In addition, tumor formation and metastasis abilities were inhibited after in vivo knockdown of TTN-AS1. |
| Pubmed ID | 31858535 |
| Year | 2019 |
| Title | Long Noncoding RNA TTN-AS1 Promotes the Proliferation and Migration of Prostate Cancer by Inhibiting miR-1271 Level |
External Links
| Links for TTN-AS1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |