Basic Information
| LncRNA/CircRNA Name | TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 |
| Ensemble | ENSG00000237298 |
| Refseq | NR_038272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Western blot analysis |
| Sample | BC cell lines (MCF-7, LCC9, T-47D, SKBR3) and normal human breast cell line (MCF-10A),BC tissues |
| Expression Pattern | up-regulated |
| Function Description | TTN-AS1 expression in BC samples was significantly higher than that of the adjacent tissues. Besides, the migration and invasion of BC cells were markedly inhibited after TTN-AS1 was silenced, while promoted after TTN-AS1 overexpression. In addition, a remarkable decrease of DGCR8 was observed after TTN-AS1 was inhibited in BC cells, while DGCR8 was upregulated after overexpression of TTN-AS1. |
| Pubmed ID | 31858552 |
| Year | 2019 |
| Title | Long Non-Coding RNA TTN-AS1 Promotes the Metastasis in Breast Cancer by Epigenetically Activating DGCR8 |
External Links
| Links for TTN-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |