Basic Information
LncRNA/CircRNA Name | TTN-AS1 |
Synonyms | NA |
Region | GRCh38_2:178521183-178779963 |
Ensemble | ENSG00000237298 |
Refseq | NR_038272 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | RT-qPCR, Western blot analysis, Dual Luciferase Reporter Assay |
Sample | CRC and pair-matched normal tissues,CRC cell lines (SW480, SW620, HT29, HCT116) and human normal colon epithelial cell (FHC) |
Expression Pattern | up-regulated |
Function Description | a significant increase of TTN-AS1 expression level in CRC tissues and cell lines compared with normal counterparts. High expression of TTN-AS1 predicted a poor prognosis and was correlated with aggressive clinicopathological characteristics in CRC patients. Functionally, gain- and loss-of-function studies indicated that TTN-AS1 knockdown suppressed the proliferation, migration, invasion and epithelial-mesenchymal transition of CRC cells in vitro, whereas TTN-AS1 overexpression showed the complete opposite effects. Mechanistically, we found that TTN-AS1 could directly interact with miR-497, and co-transfection with miR-497 mimics blocked the activation of PI3K/Akt/mTOR signaling, and reversed the effects of TTN-AS1 overexpression in CRC cells. |
Pubmed ID | 31920341 |
Year | 2019 |
Title | Long Non-Coding RNA TTN-AS1 Promotes the Proliferation and Invasion of Colorectal Cancer Cells by Activating miR-497-Mediated PI3K/Akt/mTOR Signaling |
External Links
Links for TTN-AS1 | GenBank HGNC NONCODE |
Links for colorectal cancer | OMIM COSMIC |