Basic Information
| LncRNA/CircRNA Name | TSlnc8 |
| Synonyms | LINC00589,TSLNC8, C8orf75 |
| Region | GRCh38_8:29673922-29748109 |
| Ensemble | ENSG00000251191 |
| Refseq | NR_026765 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, other |
| Sample | glioma tissues and cell lines( BE-2C and BT325) |
| Expression Pattern | down-regulated |
| Function Description | Additionally, cell metastasis was inhibited in U251 and SWO38 cells when cells were transfected with TSLNC8-expressing plasmid as observed via Transwell and wound-healing assays. Furthermore, cell apoptotic rate was upregulated in TSLNC8 plasmid-treated U251 and SWO38 cells, and inhibited by siRNA against TSLNC8 in SHG-44 and BT325 cells by cell apoptotic assay. The relative activities of caspase-3 and caspase-9 were increased by TSLNC8 overexpression and decreased by TSLNC depletion; however, the activity of caspase-8 remained unchanged.? |
| Pubmed ID | 30387847 |
| Year | 2018 |
| Title | Long noncoding RNA TSLNC8 suppresses cell proliferation and metastasis and promotes cell apoptosis in human glioma. |
External Links
| Links for TSlnc8 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |