Basic Information
| LncRNA/CircRNA Name | TRPM2-AS |
| Synonyms | TRPM2-AS, TRPM2-AS1 |
| Region | GRCh38_21:44414588-44425272 |
| Ensemble | ENSG00000230061 |
| Refseq | NR_109964 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, CCK-8 assay etc. |
| Sample | NSCLC tissues, cell lines (A549 and H1299) |
| Expression Pattern | up-regulated |
| Function Description | TRPM2-AS is widely upregulated in non-small cell lung cancer tissues compared with adjacent non-tumor tissues. We found that cell proliferation was significantly inhibited after knockdown of TRPM2-AS. Annexin V/propidium iodide staining and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay confirmed that cell apoptosis increased after TRPM2-AS knockdown. Further experiments showed that silence of TRPM2-AS upregulated SHC1 and silence of SHC1 partially reversed cell apoptosis after TRPM2-AS knockdown. |
| Pubmed ID | 28231726 |
| Year | 2017 |
| Title | Downregulation of a novel long noncoding RNA TRPM2-AS promotes apoptosis in non-small cell lung cancer. |
External Links
| Links for TRPM2-AS | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |