Basic Information
| LncRNA/CircRNA Name | TRPM2-AS |
| Synonyms | TRPM2-AS, TRPM2-AS1 |
| Region | GRCh38_21:44414588-44425272 |
| Ensemble | ENSG00000230061 |
| Refseq | NR_109964 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | HCC tissue, cell lines (HCCLM3, Huh7, SMMC-7721, SKHep1, HepG2) |
| Expression Pattern | up-regulated |
| Function Description | The expression of TRPM2-AS was higher in most HCC tissues and was significantly correlated with tumor size, AJCC stage, tumor differentiation, and the prognosis of HCC patients. Interfering TRPM2-AS expression using siRNA significantly inhibited cell proliferation and promoted cell apoptosis in two HCC cell lines. |
| Pubmed ID | 29081064 |
| Year | 2017 |
| Title | Long non-coding RNA TRPM2-AS as a potential biomarker for hepatocellular carcinoma |
External Links
| Links for TRPM2-AS | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |