Basic Information
| LncRNA/CircRNA Name | TRPM2-AS |
| Synonyms | NA |
| Region | GRCh38_21:44414588-44425272 |
| Ensemble | ENSG00000230061 |
| Refseq | NR_109964 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot |
| Sample | GC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | silencing TRPM2-AS inhibits the proliferation, metastasis and radioresistance of GC cell whereas ectopic expression of TRPM2-AS significantly improves the progression of GC cell in multiple experiments. Mechanistically, TRPM2-AS serves as a microRNA sponge or a competitive endogenous RNA (ceRNA) for tumor suppressive microRNA miR-612 and consequently modulates the derepression of IGF2BP1 and FOXM1. |
| Pubmed ID | 32123162 |
| Year | 2020 |
| Title | Long noncoding RNA TRPM2-AS acts as a microRNA sponge of miR-612 to promote gastric cancer progression and radioresistance |
External Links
| Links for TRPM2-AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |