Basic Information
| LncRNA/CircRNA Name | TRIM52-AS1 |
| Synonyms | TRIM52-AS1 |
| Region | GRCh38_5:181261212-181272307 |
| Ensemble | ENSG00000248275 |
| Refseq | NR_102759 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Cell transfection, Cell proliferation assay, Cell migration assay etc. |
| Sample | RCC tissues, cell lines (ACHN and 786-O) |
| Expression Pattern | down-regulated |
| Function Description | The results of the present study revealed that the expression of the lncRNA, TRIM52-AS1, was downregulated in RCC. Furthermore, the overexpression of TRIM52-AS1 using a synthesized vector significantly suppressed cell migration and proliferation, and induced apoptosis of the RCC cells in vitro, and interference of its expression led to the opposite effects. |
| Pubmed ID | 26934858 |
| Year | 2016 |
| Title | Downregulation of long non-coding RNA TRIM52-AS1 functions as a tumor suppressor in renal cell carcinoma. |
External Links
| Links for TRIM52-AS1 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |