Basic Information
| LncRNA/CircRNA Name | TRG-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:38341577-38378804 |
| Ensemble | ENSG00000281103 |
| Refseq | NR_040085 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Human GBM cell lines U251 and U87, normal human astrocytes (NHAs), human glioblastoma cell lines A172 and LN229, glioma tissues and normal tissues |
| Expression Pattern | up-regulated |
| Function Description | TRG-AS1 is associated with poor prognosis and is upregulated in glioblastoma tissues and cells. TRG-AS1 can also accelerate glioblastoma cell proliferation in return. On the other hand, miRNA-877-5p expresses low in glioblastoma and contains binding sites with both TRG-AS1 and SUZ12. Furthermore, TRG-AS1 suppresses the expression of miR-877-5p while miR-877-5p suppresses SUZ12 expression. Overexpression of TRG-AS1 could promote the expression of SUZ12.Rescue assays demonstrates that overexpression of SUZ12 can counteract the decline of glioblastoma cell proliferation induced by knockdown of TRG-AS1. |
| Pubmed ID | 31196742 |
| Year | 2019 |
| Title | LncRNA TRG-AS1 promotes glioblastoma cell proliferation by competitively binding with miR-877-5p to regulate SUZ12 expression |
External Links
| Links for TRG-AS1 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |