Basic Information
| LncRNA/CircRNA Name | TRERNA1 |
| Synonyms | TRERNA1, LINC00651, treRNA |
| Region | GRCh38_20:50040716-50041504 |
| Ensemble | ENSG00000231265 |
| Refseq | NR_051976 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | gastric cancer tissues, gastric cancer cell lines (MKN-28, MKN-45, Bgastric cancer-823, AGS, Mgastric cancer-803) |
| Expression Pattern | up-regulated |
| Function Description | In the present study, we demonstrate that lncRNA TRERNA1 acts like an enhancer of SNAI1 to promote cell invasion and migration and to contribute to metastasis of gastric cancer (GC). Further studies have shown that TRERNA1 not just inhibits the expression of CDH1 by enhancing SNAI1 expression, but also epigenetically silenced CDH1 by recruiting EZH2 to carry out histone methylation of its promoter region. lncRNA TRERNA1 was identified and located close to SNAI1, which is an epithelial-mesenchymal transition (EMT) master regulator transcription factor.It has been found that the expression of CDH1 is not only regulated by the transcription factor SNAI1, but also by epigenetic modification, such as microRNA (miRNA), DNA methylation, and histone modification. |
| Pubmed ID | 28918030 |
| Year | 2017 |
| Title | LncRNA TRERNA1 Function as an Enhancer of SNAI1 Promotes Gastric Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition. |
External Links
| Links for TRERNA1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |