Basic Information
| LncRNA/CircRNA Name | TRERNA1 |
| Synonyms | NA |
| Region | GRCh38_20:50040716-50041504 |
| Ensemble | ENSG00000231265 |
| Refseq | NR_051976 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | hepatocellular carcinoma tissues and paired adjacent non-tumour tissues ,immortalized human normal hepatocyte cell line LO2 and the HCC cell lines(HepG2, HepG2.215) |
| Expression Pattern | up-regulated |
| Function Description | Elevated TRERNA1 levels promoted HCC cell migration and invasion in vitro and in vivo.TRERNA1 recruited EHMT2 to dimethylate H3K9 in the CDH1 promoter region.Furthermore, EHMT2 bound to SNAI1 to suppress CDH1 expression in HCC cells. After inhibiting TRERNA1, the expression level of CDH1 was restored and was involved in the regulation of the EHMT2/SNAI1 complex.The level of TRERNA1 was positively correlated with tumour metastasis and was negatively correlated with the expression of CDH1 in HCC tissues. |
| Pubmed ID | 31012192 |
| Year | 2019 |
| Title | LncRNA TRERNA1 Facilitates Hepatocellular Carcinoma Metastasis by Dimethylating H3K9 in the CDH1 Promoter Region via the Recruitment of the EHMT2/SNAI1 Complex |
External Links
| Links for TRERNA1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |