Basic Information
| LncRNA/CircRNA Name | TRERNA1 |
| Synonyms | NA |
| Region | GRCh38_20:50040716-50041504 |
| Ensemble | ENSG00000231265 |
| Refseq | NR_051976 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | gastric cancer tissues, cell lines (AGS, SGC-7901 and BGC-823) |
| Expression Pattern | up-regulated |
| Function Description | TRERNA1 was upregulated in gastric carcinogenesis and promoted cell migration and invasion in GC. Using bioinformatics analysis, we observed that there were several potential binding sites of TFAP4 in the promoter region of TRERNA1. The knockdown of TFAP4 significantly reduced the expression level of TRERNA1, whereas the ectopic expression of TFAP4 significantly increased the expression level of TRERNA1 in GC cell lines. Dual luciferase reporter assay combined with chromatin immunoprecipitation (ChIP) revealed that TFAP4 specifically regulated the transcriptional activity of TRERNA1 by binding to the E-box motifs in the TRERNA1 promoter. In addition, there was a positive correlation between the TFAP4 and TRERNA1 expression level in clinical GC cases, which also indicated that TFAP4 can directly modulate the expression of TRERNA1. |
| Pubmed ID | 29845218 |
| Year | 2018 |
| Title | Elevated TFAP4 Regulates lncRNA TRERNA1 to Promote Cell Migration and Invasion in Gastric Cancer |
External Links
| Links for TRERNA1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |