Basic Information
| LncRNA/CircRNA Name | TPTEP1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatinum | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay , RNA-seq , Western blot etc. |
| Sample | HCC and adjacent non-cancerous liver tissues ,human HCC cell lines(HepG2, SMMC-7721, QGY-7703, Huh-7, MHCC97h, SNU-449 and Sk-hep1) ,human normal liver cell line L02 |
| Expression Pattern | up-regulated |
| Function Description | LncRNA TPTEP1 was highly expressed in cisplatinum-treated HCC cells, which sensitizes hepatocellular carcinoma cell to cisplatinum-induced apoptosis.TPTEP1 overexpression inhibited, while TPTEP1 knockdown promoted HCC cell proliferation, tumorigenicity and invasion. Furthermore, TPTEP1 exerted its tumor suppressing activities by interacting with STAT3 to inhibit its phosphorylation, homodimerization, nuclear translocation and down-stream genes transcription.TPTEP1 overexpression obviously inhibits tumor masses in vivo in a subcutaneous xenograft mouse model of HCC and TPTEP1 is frequently downregulated in HCC tissues, compared to its corresponding pre-tumor tissues. |
| Pubmed ID | 31072375 |
| Year | 2019 |
| Title | Long Non-Coding RNA TPTEP1 Inhibits Hepatocellular Carcinoma Progression by Suppressing STAT3 Phosphorylation |
External Links
| Links for TPTEP1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |