Basic Information
| LncRNA/CircRNA Name | TPTE2P1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, other |
| Sample | CRC tissues and cell lines(HCT116, DLD-1, RKO,HT-29, SW1116, SW480, LoVo, and SW620) |
| Expression Pattern | up-regulated |
| Function Description | TPTE2P1 levels were significantly higher in CRC tissues than in adjacent normal tissues. Higher expression was associated with a poor survival rate. The silencing of TPTE2P1 led to cell cycle arrest at the S phase and thereby inhibited cell viability. TPTE2P1 knockdown also caused cancer cell apoptosis via the activation of the apoptosis regulator (BCL2)/caspase 3 signaling cascade. In addition, the inhibition of TPTE2P1 had suppressive effects on tumors in vivo. TPTE2P1 is upregulated in CRC and plays essential roles in the regulation of cell viability in vitro and tumor formation in vivo. |
| Pubmed ID | 30382596 |
| Year | 2019 |
| Title | The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells. |
External Links
| Links for TPTE2P1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |