Basic Information
| LncRNA/CircRNA Name | TPTE2P1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | HCC tissues and normal tissues ,HCC cell lines(HepG2, Huh7,MHCC97, Bel7402, SMMC7721 and HCCLM3 ,normal human liver cell line HL7702 |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-TPTE2P1 was overexpressed in both HCC tissues and cell linesOverexpression of lncRNA-TPTE2P1 was correlated with tumor size, distant metastasis, differentiation degree, as well as tumor node metastasis (TNM) stage of HCC patients.Down-regulated lncRNA-TPTE2P1 could significantly suppress the invasion and migration of cells.Moreover, lowly expressed lncRNA-TPTE2P1 significantly decreased the protein levels of E-cadherin, Vimentin and N-cadherin. These results indicated that lncRNA-TPTE2P1 might stimulate the migration and invasion of HCC cells by promoting epithelial-mesenchymal transition (EMT). |
| Pubmed ID | 31114999 |
| Year | 2019 |
| Title | Long Noncoding RNA TPTE2P1 Promotes the Migration and Invasion of Hepatocellular Carcinoma |
External Links
| Links for TPTE2P1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |