Basic Information
| LncRNA/CircRNA Name | TPT1-AS1 |
| Synonyms | NA |
| Region | GRCh38_13:45341345-45393413 |
| Ensemble | ENSG00000170919 |
| Refseq | NR_024458 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | EOC tissues,cell lines (ES-2,SKOV3) |
| Expression Pattern | up-regulated |
| Function Description | TPT1-AS1 expression in metastatic EOC tissue was significantly higher than that in paired primary EOC tissue and nonmalignant ovarian tissue (P < 0.05). For instance, the expression of the lncRNA human ovarian cancer-specific transcript 2 (HOST2) was found to be upregulated in EOC tissue, promoting cell proliferation and metastasis by sponging miRNA let-7b. |
| Pubmed ID | 30941821 |
| Year | 2019 |
| Title | LncRNA TPT1-AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression. |
External Links
| Links for TPT1-AS1 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |